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cenobamate will raise the amount or result of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Observe Closely. Look at a dose reduction of CYP2C19 substrates, as clinically proper, when utilized concomitantly with cenobamate.diazepam increases amounts of lomitapide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Us